Protein Details: Potassium voltage-gated channel subfamily A member 3

Protein ID

ICDB_Pro_0404

Protein Name

Potassium voltage-gated channel subfamily A member 3

Gene Name

KCNA3; HGK5

Organism

Homo sapiens (Human)

Length

575 amino acids

AlphaFoldDB

AF-P22001-F1-model_v4.pdb

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane;the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient

Sequence

MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV

PDB Structures

4BGC 7EJ1 7EJ2 7SSV 7SSX 7SSY 7SSZ 8DFL

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Bone Development Disease and Amino Acid Metabolic Disorder

Location

DOI ID

10.1006/geno.1994.1500; 10.1038/nature04727; 10.1101/gr.2596504; 10.1073/pnas.88.1.53; 10.1016/s0021-9258(18)42492-1; 10.1089/dna.1992.11.163

RefSeq

NP_002223.3